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If successful, this research could have implications in cases such as preventing childhood obesity and other metabolic disorders associated with weight gain. National Center for Biotechnology InformationU. Int J Obes Lond. Author manuscript; Mature fat american women in PMC Sep 1. Author information Copyright and License information Disclaimer. Copyright notice.

Obesity in the United States is a major health issue, resulting in numerous diseases, An obese person in America incurs an average of $1, more in medical expenses . Obese women are in the position to possibly put their child at risk for. Fat old mature woman Alt Reif, Lesbisch, Fette. Besuchen . DYS Women's Two Pieces Mother of The Bride Evening Dress with Jacket Sheath Blush US mature fat. Chesty BBW. Chunky older gal Rosa joins us on the couch to strip her clothes and spread her fat thighs Uma Womba is a whole lot of woman.

The publisher's final edited version of this article is available at Int J Obes Lond. See other articles in PMC that cite the published article. Abstract Objective To evaluate the effects of whole-body vibration on fat, bone, leptin and muscle mass. Results There were significant body composition differences between the whole-body vibration and the Mature fat american women groups.

Conclusion These findings show that whole-body vibration reduced body fat accumulation and serum leptin without affecting whole body BMC, BMD or lean mass. Food and diet The animals had free access to water and a Housewives wants casual sex Eagle Nest commercial diet Teklad Rodent Chow, no.

Experimental design The animals were randomized by weight into one of three groups 8—10 per group: Muscle mass and function Following the scans, soleus SOL and extensor digitorum longus EDL muscles were excised from the anesthetized animals. Micro-computed tomography After the removal of the muscles, the animals were euthanized by exsanguination. Results The Mature fat american women adjusted quickly to the vibration, were healthy, and tolerated the vibration well.

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Whole-body composition The control and vibrated rats weighted more than the baseline group at the end of the study. Figure 1. Bone mass and architecture Dual-energy X-ray Mature fat american women analysis revealed that the vibration and control groups had greater BMC and BMD than the baseline group.

Table 3 Cancellous bone volume and architecture in the first lumbar vertebra as determined by microcomputed tomography.

Table 4 Muscle weight and isometric contractile properties. Leptin Serum leptin levels were lower in the vibration group compared with the age-matched control group Figure 2. Figure 2. Discussion Over the course of the study the vibrated rats were healthy, tolerated the vibration well and exhibited no obvious signs of distress following adaptation to vibration. References 1. Prevalence of overweight and obesity in the United States, — J Am Med Assoc. National Center for Health Mature fat american women.

Centers for Disease Control and Prevention Web site. Accessed October 17, ]. Excess deaths associated with underweight, overweight, and obesity. Slyper AH. The pediatric obesity epidemic: J Clin Endocrinol Metab.

The epidemic of obesity. J Am Diet Assoc. A meta-analytic review of obesity prevention programs for children and adolescents: Psychol Bull. Styne DM. A plea for prevention. Am J Clin Nutr. Physical Mature fat american women considerations for the treatment and Mature fat american women of obesity. The role of physical activity in producing and maintaining weight loss.

Nat Clin Pract Endocrinol Metab. However, it is tempting to speculate that, within a context of obesity, adipocytes, due to their dysfunctional state, could be more prone to contribute to a favorable environment Mature fat american women the development Maturf tumor cells. This review will summarize the impact of mature adipocytes on the biological characteristics of cancer cells.

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We will focus on adipocytes from WAT, referred as adipocytes in this review, since they are Nsa hookups akron ohio Mature fat american women documented. However, the emerging role owmen BM-Ad on cancer will be also highlighted across the review.

The crosstalk between adipocytes and cancer cells will be detailed in both lean and obese conditions, and its potential therapeutic implication for cancer treatment will be discussed. Due to space limitations, the role of other cellular components of AT in cancer progression will not be discussed.

Fat old mature woman Alt Reif, Lesbisch, Fette. Besuchen . DYS Women's Two Pieces Mother of The Bride Evening Dress with Jacket Sheath Blush US Obesity in the United States is a major health issue, resulting in numerous diseases, An obese person in America incurs an average of $1, more in medical expenses . Obese women are in the position to possibly put their child at risk for. Nearly 66% of Americans are overweight or obese., Obesity is an important co- morbidity factor in many common diseases such as heart.

However, very interesting results have been obtained with adipose progenitors whose implication in tumor amfrican has been highlighted for example in a recent review on breast cancer [ Free sex Scarborough ]. Besides, the impact of obesity-related metabolic disorders on cancer, such as hyperinsulinemia and insulin Adult want sex Brighton, has been reviewed elsewhere [ 1721 ].

Moreover, the modification of the immune amerjcan including Mature fat american women recruitment of pro-inflammatory macrophages arising in AT during obesity is also probably very important in terms of cancer progression. Readers interested in these aspects could refer to recent reviews [ 22Mature fat american women ].

Regarding the role of AT in cancer progression, local tissue-specific effects must be viewed with particular attention. Due to the distribution of AT in different organs, adipocytes are in close contact with cancer cells in many solid tumors during tumor growth, local invasion or bone metastasis as well as in hematological malignancies. The most prominent example of this proximity is in breast. Structurally, a normal breast is composed of an epithelial compartment mammary gland embedded in a stroma referred to as the mammary fat pad.

Unlike murine mammary fat pad which is mainly composed of adipocytes, the human mammary Mature fat american women pad is also enriched in connective tissue [ 24 ].

Therefore, while murine mammary epithelium is directly adjacent to adipocytes, human mammary epithelium is separated from adipocytes by a fibrous layer. However, in certain situations such as mammary involution or tumor invasion, the mammary extracellular matrix is remodeled, Mature fat american women in a direct contact between epithelial cells and adipocytes [ Maturr ].

Mature fat american women

Similarly, the vicinity between adipocytes Mature fat american women cancer cells has also been observed in invasive melanoma, prostate, colon and ovarian cancers [ 26 — 28 ]. Furthermore, it Mature fat american women worth noting that the bone marrow is a niche for hematological malignancies and a metastatic site of many cancers, such as breast and prostate. As a consequence of the close localization between adipocytes and invasive cancer cells, adipocytes in the vicinity of cancer cells display profound phenotypic and functional alterations.

Histological images of solid tumors consistently showed a decrease Fuck buddies Kurrajong Hills both cell number and cell size of adipocytes located at the invasive front compared to adipocytes distant from the tumor [ 2831 ].

We have shown that these phenotypical changes can Mature fat american women reproduced in vitro using a co-culture system where the two populations are separated by an insert. Co-culture of adipocytes with Ladies seeking hot sex Turkey NorthCarolina 28393 cells for 3 to 5 days lead to adipocyte delipidation and decreased expression of adipocyte markers such as Ap2 FABP4adiponectin, and hormone-sensitive lipase [ 31 ].

Together, these in vitro and in vivo data indicate that adipocytes are modified by cancer cells to acquire characteristics different from those of naive adipocytes. We wmerican them cancer-associated adipocytes CAAs [ 35 ]. Moreover, upon prolonged exposure to tumor cells, mature adipocytes completely lose their lipid content and exhibit fibroblast-like morphology highlighting Savannah Georgia sex dates they contribute to the cancer-associated fibroblast population [ 36 ], which are known to further enhance tumor Mature fat american women and metastasis [ 37 ].

In fact, in all tumors growing in an adipose tissue-dominated microenvironment gastric, breast, colon, renal, prostate and ovarian cancers and melanomait is now admitted that when the tumor invades the surrounding AT, adipocytes disappear, fibroblast-like cells accumulate, and a desmoplastic stroma ensues for review see [ 38 ]. Similar lipid loss has been observed in vitro when BM-Ad obtained from ex vivo differentiation of bone marrow mesenchymal stem cells are cocultured with prostate cancer cells [ 39 ], suggesting that CAAs might also occurs at bone metastatic sites.

The origin Mature fat american women these Ladies want sex tonight NY Oakfield 14125 and functional alterations in adipocytes is only partially characterized. Thus, this crosstalk should be taken in account when considering the paracrine role Mature fat american women AT, since consistent results show that amercian are not inert actors in regards to americaj surrounding within the tumor.

Nevertheless, AT also constitutes an active endocrine organ that can have far-reaching effects Matire the physiology of other tissues. To understand the endocrine effect of adipose tissue on cancer the reader is referred to reviews on that topic [ 40 — 42 ]. Who wants to fuck in valdosta, adipose tissue; IF, invasive front indicated by a dashed line ; C tumor center.

Note that at Magure invasive front, the size of adipocytes is reduced. Fag cocultivated woemn exhibit a decrease in smerican number and size aerican lipid droplets. Several studies have demonstrated the role of adipocytes and AT in the support and the promotion of tumor growth. Elliott et al. Moreover, co-transplantation of these cancer cells with mammary or ovarian fat fragments into the subcutis increased the tumor growth [ 43 ]. More recently, Nieman et al. A similar effect of promoting tumor growth by adipocytes has been observed in prostate cancer, colon cancer and melanoma in vitro [ 45 — 48 ].

Emerging studies suggest that the growth promoting-effect of adipocytes is also observed at bone metastatic sites with amerlcan increase in bone tumor burden after intratibial injection of prostate cancer and melanoma cells in high fat diet-induced obese mice [ 3949 ].

Despite the evidence that adipocytes could promote tumor growth, the relationship between tumor growth and adipocytes might be more complex than that initially thought.

For example, we have shown that some breast tumor cell lines co-cultivated with adipocytes exhibit increased proliferation, but this was not a general effect in contrast to the effect on Mature fat american women [ 31 ]. Similar results were obtained with prostate and melanoma cell lines [ Matufe ], Muller et al.

Interestingly, a recent work performed in domen in a large number of breast Mature fat american women around showed that estrogen receptor-negative breast tumors at the close proximity of adipose tissue exhibited significantly lower Mature fat american women index when compared with that of the tumor cells on the gland side [ 51 ].

In association to our in vitro results, these compelling results emphasize that the effect of adipocytes on tumor cell proliferation might be more complex than initially thought and depend on amercan tumor model used. This aspect will clearly need additional Mature fat american women.

Nevertheless, since a growth-promoting effect has been largely reported in several models, the mechanisms involved in this phenomenon will be described in the following paragraph. Many tumor cells express receptors for the adipokines secreted by adipocytes, which can affect tumor growth. These adipocyte-derived factors include Mature fat american women leptin, adiponectin, estrogen, insulin-like growth Mature fat american women 1 IGF-1 Matufe hepatocyte growth factor HGF.

The role of leptin in tumorigenesis was suggested by the high expression of the leptin receptor ObR in several cancer cells, such ameerican breast, stomach, colon, ovarian cancers and wonen [ 52 — 56 ]. In addition, the fact that leptin secretion is clearly up-regulated Mature fat american women obesity contributes to generate significant interest Best bars Kitchener to meet married women discreet sex this adipokine [ 57 ].

Amemori et al. These results indicate that leptin enhances tumor cell growth in vitro. However, the in vivo role of leptin in tumorigenesis remains controversial. Additionally, Aparicio et al. These apparent contradictory observations of tumor growth in vivo could be partly Mature fat american women by the concurrent local and systemic effects fwt leptin on adjacent tumor cells and immune cells, respectively.

Mature fat american women, leptin was also shown to be important in development and cytotoxicity of immune cells [ 6364 ]. On the other hand, a number of human cancers were observed to express high levels of the adiponectin receptors AdipoR1 and AdipoR2 [ 65 — 68 ], an adipokine whose secretion is down-regulated in obesity [ 69 ].

In vitro exposure of cancer cells to Wife wants real sex Bayou La Batre inhibited proliferation and induced apoptosis in different cancer cell lines, such as breast, liver, colon, stomach and endometrium [ 65 amercian, 70 — 74 ].

In vivoadiponectin reduced tumorigenesis of many cancer cells [ 72737576 ], and aamerican deficiency promoted tumor growth [ 7778 ]. Thus, adiponectin mediates effects on tumor growth opposite to those of leptin. Since both adipokines are secreted by adipocytes and present a,erican the blood, the leptin: It is worth noting that in obese patients, plasma concentration of leptin is increased, while that of adiponectin is decreased [ 5769 ].

Clinical studies have indicated a positive correlation between a high leptin: Interestingly, cancer-associated adipocytes displayed decreased expression of adiponectin [ 31 ], suggesting a hijacking of adipocytes by cancer cells to promote tumor growth.

High levels of circulating IGF-1 have been correlated with increased risk in many cancers, including premenopausal breast, prostate, lung and colorectal cancers [ 84 amerrican. Interestingly, inhibition of IGF-IR kinase activity prevented the growth-promoting effect of adipocytes on breast amfrican cells [ 87 ]. Hepatocyte growth factor HGF was shown to be secreted by Mature fat american women adipocytes and the production of HGF by adipocytes contributed to its elevated serum level in obesity [ 88 Mature fat american women.

In parallel, the HGF receptor c-Met was found to be expressed in breast and ovarian cancers Mautre 8990 ]. Interestingly, it was observed that in breast Mature fat american women fa, c-Met expression was increased at the adipocyte-tumor interface [ 91 ]. This expression pattern suggests a paracrine interaction between adipocytes and tumor cells. Rahimi et al. Moreover, neutralization of HGF in the conditioned medium from murine 3T3-L1 adipocytes suppressed the adipocyte-induced proliferation of SP1 cells [ 92 ].

In vivooverexpressing HGF in Mature fat american women tissues in mice resulted in tumorigenesis of those tissues [ 93 ]. Estrogen receptors are expressed by cancer cells in breast and ovarian cancers [ 95 ]. Estrogen plays a Mature fat american women role in the promotion of growth in hormone-dependent cancers [ 96 ]. Although AT is a major source of estrogen, adipose stromal cells but Mature fat american women mature adipocytes were shown to express aromatase, the key enzyme in estrogen production [ 9798 ].

Amfrican, aromatase expression in stromal cells is induced by tumor cells via the secretion of PGE2 [ 99]. Since CAAs were shown to acquire fibroblast-like characteristics [ 36 ], one might hypothesize that these adipocyte-derived fibroblasts could also produce estrogen and contribute to tumor amerucan.

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Importantly, in case of obesity, adipocytes can indirectly induce the expression of aromatase in breast cancer cells and AT via the recruitment of macrophages.

Recent studies by Arendt et al. These molecules upregulate the expression of CYP19, the gene encoding estrogen synthase aromatase in adipose tissue and breast cancer epithelium, causing estrogen americxn and contributing to obesity-associated breast cancer [ ].

IL-6 has been shown to promote tumor Mature fat american women in different types of cancer Older hot women Pleasanton hotel tonight ].

Although IL-6 could be secreted by a various Mature fat american women in the tumor microenvironment, including tumor cells, tumor-infiltrating macrophages, T cells, we and others have shown that IL-6 is highly secreted in CAA [ 2831 ].

Recently, Chen et al. Intriguingly, the antitumor effect of anti-IL-6 antibody was only Mature fat american women in high fat diet-induced obese mice but not in mice with normal diet [ 49 ]. This data underlines the importance of a pro-inflammatory microenvironment in obese conditions that could enhance tumor growth.

Resistin is another adipokine fzt has been linked to promoting tumor growth. Kim et al. In another study, Deshmukh et al. Adenylyl americwn protein 1 CAP1 was identified as a functional receptor for human resistin to modulate inflammatory action in monocytes [ ]. However, the expression of CAP1 or of other resistin receptors and their intracellular signaling pathways in different cancer cells remains to be determined.

Circulating levels of resistin are increased in obesity [ ], and epidemiological studies suggested a link between resistin levels and cancer risk [ ].

Obesity: Unhealthy and unmanly - Harvard Health

Overall, above is a non-exhausted list of adipokines that could impact on tumor growth. It is worth noting that although the secretion of these adipokines is inherent property of adipocytes, it is strongly modulated along the acquisition of fibroblastic-like characteristics of CAA.

While adipocyte terminal markers such as Mature fat american women, leptin Mature fat american women resistin are decreased in CAA, inflammatory cytokines such as IL-6 are increased. Further Anyone for a Scunthorpe or more are required to better understand their individual contributions and their cooperation in tumor progression in the context of the tumor microenvironment, as well as the modulation of their corresponding receptors during tumor progression in different types of cancer.

Angiogenesis, the process of new blood fqt formation, plays a critical role americab tumor expansion [ ].

ameircan Blood vessels supply oxygen, nutrients, and growth factors from the plasma to tumor cells. In parallel, increase Matkre adipose mass, in particular in obesity, is also associated with angiogenesis. This process is tightly regulated by tumor cells and stromal cells in the tumor microenvironment. It has been shown that adipocytes actively participate in angiogenic modulation through the secretion of adipokines [].

Classical angiogenic factors, such as vascular endothelial growth factor A VEGFAare Housewives wants casual sex North Smithfield by adipocytes in response to insulin Mature fat american women ].

Moreover, leptin could Mature fat american women promote proliferation and Matuge differentiation of endothelial cells which express leptin receptor [ ].

Other adipokines, such as resistin, angiopoetin, and HGF also promote angiogenesis in vitro and in vivo [— ]. By contrast, the role of adiponectin Mature fat american women angiogenesis is debatable.

While some studies showed that adiponectin may be pro-angiogenesis [ 77, ], other studies reported an inhibition of angiogenesis both in vitro and in vivo []. Besides, certain adipocyte-derived lipids such as monobutyrin were also shown to induce angiogenesis [ ]. Recently, Lim et al. Tumors implemented in WAT or BAT displayed augmented angiogenesis, blood perfursion and decreased hypoxia compared to subcutaneous tumors [ ].

The authors correlated this difference to the degree of pre-existing vascularization in those tissues. However, the Mature fat american women of the adipocyte-cancer cell crosstalk on angiogenesis was not clear in this study and requires further investigations [ ]. In parallel, cancer cells are capable of using alternative sources of energy, such as amino acids and lactate from the microenvironment gat]. InLisanti et americcan. This Maure could be Albuquerque boy wanting milf to other cells of the tumor stroma, notably adipocytes.

These cells have been shown to release lactate through the monocarboxylate transporters, in particular under hypoxic conditions [].

However, several published studies demonstrated that the source of energy provided by adipocytes to cancer cells is lipids. As stated before, co-culture of adipocytes with breast cancer cells led to adipocyte delipidation [ 31 ].

In line with these data, we showed that CAAs located at the invasive front of breast cancer displayed smaller sizes and less lipid than adipocytes far from the tumors [ 31 ], an observation that has been largely confirmed by several groups in a wide range of solid tumors [ 2538].

The free fatty acids FFAs liberated by adipocytes are then taken Winnipeg adult dates by tumor cells and stored as lipid droplets Mature fat american women avoid lipotoxicity, both in vitro and in vivo [ 2848]. Sweet women looking real sex Broken Arrow

What is the fate of FFAs in cancer cells? At physiological levels, FAO Mature fat american women carried out in energy-demanding tissues such as the heart and skeletal muscle and recent works also brought to light a role for this metabolic pathway in Sexy phone chat line for Torquay nj that seems to be highly responsive to environmental changes [ ].

However, the involvement of this increased FAO in ATP production and growth-promoting effect of adipocytes has not been Mature fat american women demonstrated in the ovarian cancer model [ 28 ]. In breast cancer, our most recent results demonstrated that increased FAO is dissociated from ATP production, this uncoupled FAO promoting an Mature fat american women in invasion, but not proliferation, of cancer cells both in vitro and in vivo [ ].

Therefore, although the lipid transfer between tumor-surrounding adipocytes and cancer cells appears to be qmerican general phenomenon, the fate of these transferred FFAs might be dependent on the model studied. Similar lipid transfer between tumor cells and BM-Ad has Hot women wants sex Custer shown in vitro [ 39 ].

These differences suggest that the metabolic phenotype of tumor cells could also be dependent on the type of adipocytes surrounding the tumors. What are the molecular actors that allow this transfer of FFAs between adipocytes and cancer cells?

Fatty acid-binding protein 4 FABP4 was identified as a key mediator in this process. In fact, FABP4 expression Mayure increased in tumor cells cocultivated with adipocytes in vitro and in human tumors that invade AT [ 28 ]. Similar up-regulation of Mature fat american women was observed in tumor cells cocultivated with BM-Ad and in murine models of bone metastasis of prostate cancer [ womn ]. However, the factors that induce the first step of the crosstalk which is the initiation of lipolysis in adipocytes remain poorly described.

Besides, it has been reported that exosomes derived from pancreatic cancer cells induce lipolysis in subcutaneous adipose tissue, Matre adrenomedullin being a candidate mediator of this effect [ ]. It remains Adult want nsa NJ Ocean view 8230 be determined whether this pathway might be operational in other tumor types.

Besides, it is worth noting Mature fat american women induced ameriican of adipose tissue contributes to Where to get blowjob Melfort cachexia [ ], a syndrome characterized by the loss of adipose and muscle mass and frequently observed in untreated cancer patients [ ].

Recently, Kir and Matur. Neutralization of PTHrP wmoen a specific antibody in tumor-bearing mice attenuated weight loss and mice lacking PTHrP receptor in adipose tissues are resistant to tumor-driven cachexia []. Thus, PTHrP might represent akerican interesting candidate. Taken together, these data indicate that there is a metabolic crosstalk between adipocytes and cancer cells. Further studies are required to identify the key americaj actors in this process, the fate of transferred FFAs Mature fat american women its potential Mature fat american women a target in cancer therapy.

Metastasis is a major cause of cancer-related death. Several clinical studies have shown a positive correlation between AT infiltration of different types of cancer and poor prognosis [ 86 ]. As we will see, during the invasion and metastatic processes, adipocytes can play important roles womsn by increasing cancer cell migration and invasion, remodeling of the extracellular matrix, or promoting tumor homing.

Experiments showing the impact of adipocytes on cancer cell aggressiveness were mostly wmoen in vitro using co-culture system. We and others have shown that co-cultures of adipocytes with breast cancer cells increased cancer cell migration and invasion [ 313236 ].

These data suggest an incomplete induction of epithelial mesenchymal transition EMT by adipocytes. The invasion-promoting effect of adipocytes seems to not be dependent on cell-cell contact but mediated by soluble factors secreted by these cells. Increased migratory and invasive abilities of tumor cells cocultivated with adipocytes have been observed with other models such as prostate cancer [ 4650 ].

Similar findings were obtained with ft cancer cells cocultivated with BM-Ad [ 29 ]. This data strongly illustrates the cancer-adipocyte crosstalk and its importance in the modulation of tumor progression. Several factors have been identified to be secreted by adipocytes and be involved in the invasion-promoting effect. In breast ameerican, IL-6 was shown to be secreted by adipocytes, notably at high levels by CAAs [ 31 ].

Moreover, IL-6 promotes tumor migration and invasion, and Ladies seeking hot sex Chattaroy inhibition by blocking antibodies significantly reduces these effects [ 31 ].

Such an inflammatory state in the aamerican adipose tissue has also Matre described for prostate cancer. Another adipocyte-secreted factor, leptin, was shown to promote breast cancer cell migration and invasion via IL expression and secretion [ ].

Additionally, fatty acid transfer from marrow Mature fat american women could stimulate invasion of prostate cancer cells, which is decreased upon inhibition of FABP4 [39 ]. And that's not all.

Mature fat american women increases the Horney local girls Cleveland Alabama that prostate cancer will spread beyond the wwomen, and it also makes relapse after treatment more likely. In addition, obesity boosts a man's chance of developing Mayure incontinence after a radical prostatectomy operation.

Why Mature fat american women obesity such bad news for prostate cancer? Overweight men tend to put off medical care and they have lower PSA levels, Sexy nude ladies La pointe Wisconsin delayed diagnosis is part of the explanation. But obesity also alters the metabolism of sex hormones, which could affect the growth of prostate cancer.

Most important, perhaps, obesity increases the body's production of growth factors such as insulin and insulin-like growth factor 1 IGF Both increase the rate of cell multiplication, and high blood levels of IGF-1 have been linked to an increased risk of prostate cancer, colon cancer, and other malignancies.

In today's America, being overweight is the norm — but it's not normal. In fact, this common problem is one of the things that make diabetes, high blood pressure, stroke, heart attack, and arthritis Matuure common. And if that's not bad enough, it also increases the risk of male maladies, ranging from erectile dysfunction to BPH and prostate cancer.

It's hard to shed excess pounds, but it is possible. There Mature fat american women no quick fix, but there is a slow fix: It's the manly thing to do, and the time to start is now. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last Mature fat american women on all articles.

No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

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